薬剤部の研究

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業績

 

2001年

Junichi Goto, Masanori Nagata, Nariyasu Mano, Norihiro Kobayashi, Shigeo Ikegawa, and Reiko Kiyonami:
Bile acid acyl adenylate: a possible intermediate to produce a protein-bound bile acid.
Rapid Commun. Mass Spectrom., 15, 104-109 (2001).

Naoya Kishi, Nariyasu Mano, and Naoki Asakawa:
Direct injection method for quantitation of endogenous leukotriene E4 in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry with a column-switching technique.
Anal. Sci., 17, 709-713 (2001).

Shigeo Ikegawa, Ni Made Ria Isriyanthi, Masanori Nagata, Kenji Yahata, Hiromi Ito, Nariyasu Mano, and Junichi Goto:
The enantioselective immunoaffinity extraction of an optically active ibuprofen-modified peptide fragment.
Anal. Biochem., 296, 63-72 (2001).
DOI: 10.1006/abio.2001.5198

Takashi Iida, Takeru Yamaguchi, Ryusei Nakamori, Masahiro Hikosaka, Nariyasu Mano, Junichi Goto, and Toshio Nambara:
A highly efficient, stereoselective oxyfunctionalization of unactivated carbons in steroids with dimethyldioxirane.
J. Chem. Soc., Perkin Trans. 1, 2001, 2229-2236 (2001).
DOI: 10.1039/b104938k

Nariyasu Mano, Masashi Uchida, Hiroko Okuyama, Ikuko Sasaki, Shigeo Ikegawa, and Junichi Goto:
Simultaneous detection of cholyl adenylate and coenzyme A thioester utilizing liquid chromatography/electrospray ionization mass spectrometry.
Anal. Sci., 17, 1037-1042 (2001).

1998年

Nariyasu Mano, Yoshiya Oda, Yasushi Ishihama, Hiroyuki Katayama, and Naoki Asakawa:
Investigation of interactions between drug enantiomers and flavoprotein as a chiral selector by affinity capillary electrophoresis.
J. Liq. Chromatogr. Relat. Technol., 21, 1311-1332 (1998).

Yasushi Shikata, Hiroshi Ohe, Nariyasu Mano, Manabu Kuwada, and Naoki Asakawa:
Structural analysis of N-linked carbohydrate chains of Funnel Web Spider (Agelenopsis aperta) venom peptide isomerase.
Biosci. Biotechnol. Biochem., 62, 1211-1215 (1998).

Shigeo Ikegawa, Takaaki Goto, Nariyasu Mano, and Junichi Goto:
Substrate specificity of THCA-CoA oxidases from rat liver light mitochondrial fractions on dehydrogenation of 3α,7α,12α-trihydroxy-5β-cholestanoic acid CoA thioester.
Steroids, 63, 603-607 (1998).

1997年

Nariyasu Mano, Yoshiya Oda, Koji Yamada, Naoki Asakawa, and Kouichi Katayama:
Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry.
Anal. Biochem., 244, 291-300 (1997).

1996年

Nariyasu Mano, Yoshiya Oda, Susumu Takakuwa, Shigeru Chiku, Hiroshi Nakata, and Naoki Asakawa:
Plasma direct injection high-performance liquid chromatographic method for simultaneously determining E3810 enantiomers and their metabolites by using flavoprotein-conjugated column.
J. Pharm. Sci., 85, 903-907(1996).

1995年

Susumu Takakuwa, Shigeru Chiku, Hiroshi Nakata, Teruaki Yuzuriha, Nariyasu Mano, and Naoki Asakawa:
Enantioselective high-performance liquid chromatographic assay for determination of the enantiomers of a new anti-ulcer agent, E3810, in beagle dog plasma and rat plasma.
J. Chromatogr. B, 673, 113-122 (1995).

Shigeo Ikegawa, Hiroo Watanabe, Takaaki Goto, Nariyasu Mano, Junichi Goto, and Toshio Nambara:
Stereospecific dehydrogenation of (25R)- and (25S)-3α,7α,12α-trihydroxy-5β-cholestanoic acids by acyl-CoA oxidase in rat liver light mitochondrial fraction.
Biol. Pharm. Bull., 18, 1041-1044 (1995).

Yoshiya Oda, Nariyasu Mano, and Naoki Asakawa:
Quantitation of platelet-activating factor in biological samples using liquid chromatography/mass spectrometry with column-switching technique.
Anal. Biochem., 231, 141-150 (1995).

Yoshiya Oda, Nariyasu Mano, and Naoki Asakawa:
Simultaneous determination of thromboxane B2, prostaglandin E2 and leukotriene B4 in whole blood by liquid chromatography/mass spectrometry.
J. Mass Spectrom., 30, 1671-1678 (1995).

Nariyasu Mano, Yasushi Ishihama, Yoshiya Oda, and Naoki Asakawa:
Relationship between the association constant and enantioselectivity on the flavoprotein-conjugated chiral stationary phase for high-performance liquid chromatography.
Anal Sci., 11, 983-987 (1995).

1994年

Naoki Asakawa, Hiroshi Ohe, Yoshiya Oda, Nariyasu Mano, Yasushi Shikata, Yutaka Yoshida, and Tadashi Sato:
A new postcolumn addition method of matrix for microbore liquid chromatography/frit-fast atom bombardment mass spectrometry.
J. Mass Spectrom. Soc. Jpn., 42, 25-33 (1994).

Nariyasu Mano, Yoshiya Oda, Hiroshi Ohe, Naoki Asakawa, Yutaka Yoshida, and Tadashi Sato:
Resolution of 4-(4-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4yl)-1(2H)-phthalazinone enantiomers in plasma with frit-FAB LC-MS using a conalbumin column.
J. Pharm. Biomed. Anal., 12, 557-567 (1994).

Yoshiya Oda, Nariyasu Mano, Naoki Asakawa, Yutaka Yoshida, and Tadashi Sato:
Investigation of retention behavior for racemate drugs on avidin- and modified avidin-column.
J. Liq. Chromatogr., 17, 3393-3409 (1994).

Yasushi Ishihama, Nariyasu Mano, Yoshiya Oda, Hironobu Hiyoshi, Hironori Ikuta, and Yutaka Yoshida:
Simple and sensitive quantitation method for mevalonic acid in plasma using gas chromatography/mass spectrometry.
Rapid Commun. Mass Spectrom., 8, 377-380 (1994).

Roger Klein, Irene Tatischeff, Gisele Tham, and Nariyasu Mano:
Chiral lumazines; Preparation, properties, enantiomeric separation.
Chirality, 6, 564-571 (1994).

Nariyasu Mano, Yoshiya Oda, Naoki Asakawa, Yutaka Yoshida, Tadashi Sato, and Toshinobu Miwa:
Studies of ovomucoid-, avidin-, conalbumin- and flavoprotein-conjugated chiral stationary phases for separation of enantiomers by high-performance liquid chromatography.
J. Chromatogr. A, 687, 223-232 (1994).

1993年

Yoshiya Oda, Nariyasu Mano, Naoki Asakawa, Yutaka Yoshida, Tadashi Sato, and Terumichi Nakagawa:
Comparison of avidin and ovomucoid as chiral selectors for the resolution of drug enantiomers by high-performance liquid chromatography.
Anal. Sci., 9, 221-228 (1993).

1992年

Nariyasu Mano, Yoshiya Oda, Toshinobu Miwa, Naoki Asakawa, Yutaka Yoshida, and Tadashi Sato:
Conalbumin-conjugated silica gel, a new chiral stationary phase for high-performance liquid chromatography.
J. Chromatogr., 603, 105-109 (1992).

Nariyasu Mano, Yoshiya Oda, Naoki Asakawa, Yutaka Yoshida, Tadashi Sato, and Toshinobu Miwa:
Development of a flavoprotein column for chiral separation by high-performance liquid chromatography.
J. Chromatogr., 623, 221-228 (1992).

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