薬剤部の研究

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業績

 

2015年

Taku Obara, Shinya Abe, Michihiro Sato, Sergio Ramón Gutiérrez Ubeda, Shoko Yoshimachi, Teruaki Goto:
Awareness regarding clinical application of pharmacogenetics among Japanese pharmacists.
Pharmacogenomics and Personalized Medicine, 8, 35-41 (2015).
DOI: 10.2147/PGPM.S71813

Taku Obara, Sergio Ramón Gutiérrez Ubeda, Takayoshi Ohkubo, Hideo Matsuura, Toshihiko Ishimitsu, Masanobu Takata, Hiromi Rakugi, Yutaka Imai; On behalf of Japanese Society of Hypertension recurrently education committee:
Awareness of the Japanese Society of Hypertension Guidelines for the Management of Hypertension and their use in clinical practices: 2009 survey results.
Hypertens Res,38(6),400-4(2015).
DOI:10.1038/hr.2015.21

Ayako Furugen, Hiroaki Yamaguchi, Nariyasu Mano:
Simultaneous quantification of leukotrienes and hydroxyeicosatetraenoic acids in cell culture medium using liquid chromatography/tandem mass spectrometry.
Biomed Chromatogr,29(7),1084-93(2015).
DOI: 10.1002/bmc.3395

Michihiro Satoh, Yumi Tanno, Miki Hosaka, Hirohito Metoki, Taku Obara, Kei Asayama, Kazuhiko Hoshi, Masakuni Suzuki, Nariyasu Mano, Yutaka Imai:
Salt intake and the validity of a salt intake assessment system based on a 24-h dietary recall method in pregnant Japanese women.
Clin Exp Hypertens, 37, 459-462 (2015).
DOI: 10.3109/10641963.2015.1057832

Ai Sasaki, Hayato Fukuda, Narumi Shiida, Nubuaki Tanaka, Ayako Furugen, Jiro Ogura, Satoshi Shuto, Nariyasu Mano and Hiroaki Yamaguchi:
Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.
Anal Bioanal Chem, 407(6), 1625-39 (2015).
DOI 10.1007/s00216-014-8412-5

Hiroaki Yamaguchi, Yasuhiro Shimada, Tomoya Takeda, Takashi Nakamura and Nariyasu Mano:
A novel extraction method based on a reversible chemical conversion for the LC/MS/MS analysis of the stable organic germanium compound Ge-132.
Anal. Chem., 87(4), 2042-7 (2015).
DOI:10.1021/ac504466u

Masamitsu Maekawa, Miki Shimada, Kousaku Ohno, Masami Togawa, Hiroshi Nittono, Takashi Iida, Alan F. Hofmann, Junichi Goto, Hiroaki Yamaguchi, Nariyasu Mano:
Focused metabolomics using liquid chromatography/electrospray ionization tandem mass spectrometry for analysis of urinary conjugated cholesterol metabolites from patients with Niemann–Pick disease type C and 3β-hydroxysteroid dehydrogenase deficiency.
Ann Clin Biochem,52(5),576-87(2015).
DOI: 10.1177/0004563214568871

Yuriko Murai, Hiroyuki Suzuki, Masaru Mori, Hidehisa Tasaka, Naoto Suzuki, Miki Shimada, Hiroshi Sato, Noriyasu Hirasawa, Nariyasu Mano, Yoshihisa Tomioka:
Outcomes of a Long-Term Case Review Program during the On-Site Training of Pharmacy Students.
YAKUGAKU ZASSHI., 135(7), 917-23 (2015).
DOI:10.1248/yakushi.15-00001

Takehiro Suzuki, Hiroaki Yamaguchi, Motoi Kikusato, Tetsuro Matsuhashi, Akihiro Matsuo, Takeya Sato, Yuki Oba, Shun Watanabe, Daichi Minaki, Daisuke Saigusa, Hiroko Shimbo, Nobuyoshi Mori, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yoichi Takeuchi, Akinori Yuri, Koichi Kikuchi, Takafumi Toyohara, Chitose Suzuki, Masahiro Kohzuki, Jun-ichi Anzai, Nariyasu Mano, Shigeo Kure, Teruyuki Yanagisawa, Yoshihisa Tomioka, Masaaki Toyomizu, Sadayoshi Ito, Hitoshi Osaka, Ken-ichiro Hayashi, Takaaki Abe:
Mitochonic Acid 5 (MA-5), a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases.
Tohoku J. Exp. Med., 236(3), 225-232 (2015).
DOI: 10.1620/tjem.236.225

NAOKO KITAMURA, KAZUHO SAKAMOTO, TOMOYUKI ONO, JUNKO KIMURA:
THE INHIBITORY EFFECT OF PACLITAXEL ON (KV2.1) K+ CURRENT IN H9c2 CELLS.
Fukushima J. Med. Sci., 61(1), 47-53(2015).
[Advance Publication] Released: May 19, 2015.
DOI: 10.5387/fms.2014-34

Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Koichi Node, Yutaka Imai, Takayoshi Ohkubo:
Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study.
J. Hypertens., 33(8), 1536-41 (2015).
DOI: 10.1097/HJH.0000000000000570

Michihiro Satoh, Masahiro Kikuya, Miki Hosaka, Kei Asayama, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo:
Association of Aldosterone-to-Renin Ratio With Hypertension Differs by Sodium Intake: The Ohasama Study.
Am. J. Hypertens., 28(2), 208-15 (2015).
DOI: 10.1093/ajh/hpu115

Naoto Nakagawa, Yuriko Murai, Makiko Yoshida, Hiroyuki Suzuki, Nariyasu Mano:
Effects of an evidence-based medicine workshop on Japanese pharmacy students' awareness regarding the importance of reading current clinical literature.
J. Pharm. Health Care Sci.,1(23), (2015).
DOI: 10.1186/s40780-015-0024-5

Taku Obara, Hiroaki Yamaguchi, Michihiro Satoh, Yutaro Iida, Takamasa Sakai, Yoshiko Aoki, Yuriko Murai, Masaki Matsuura, Mayumi Sato, Takayoshi Ohkubo, Ken Iseki, Nariyasu Mano:
Prevalence, determinants, and reasons for the non-reporting of adverse drug reactions by pharmacists in the Miyagi and Hokkaido regions of Japan.
Adv Pharmacoepidemiol Drug Saf., 4(4),(2015).
DOI: 10.4172/2167-1052.1000191

Chiharu Tsukada, Takahiro Saito, Masamitsu Maekawa, Nariyasu Mano, Akifumi Oda,Noriyasu Hirasawa, Masahiro Hiratsuka:
Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation.
Drug Metab Pharmacokinet., 30(5), 366-73 (2015).
DOI: 10.1016/j.dmpk.2015.07.003

Miki Shimada, Hoshimi Okawa, Yasuteru Kondo, Takahiro Maejima, Yuta Kataoka, Kanehiko Hisamichi, Masamitsu Maekawa, Masaki Matsuura, Yuko Jin, Masaru Mori, Hiroyuki Suzuki, Tooru Shimosegawa, Nariyasu Mano:
Monitoring serum levels of sorafenib and its N-oxide is essential for long-term sorafenib treatment of patients with hepatocellular carcinoma.
Tohoku J Exp Med., 237(3), 173-82 (2015).
DOI: 10.1620/tjem.237.173

Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Miki Hosaka, Megumi Tsubota-Utsugi, Taku Obara, Aya Ishiguro, Keiko Murakami, Ayako Matsuda, Daisaku Yasui, Takahisa Murakami, Nariyasu Mano, Yutaka Imai, and Takayoshi Ohkubo:
Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study.
Hypertension, 67, 48-55 (2015).
DOI: 10.1161/HYPERTENSIONAHA.115.06461

Taku Obara, Michihiro Satoh, Nobuhiro Ooba, Yoshihiko Morikawa, Hidekazu Nishigori, Nariyasu Mano:
Prescription of drugs for children with attention-deficit/hyperactivity disorder (ADHD) in Japan: a study based on health insurance claims data
J. Drug Interact Res. , 32(2), 9-17 (2015).
DOI: 10.1161/HYPERTENSIONAHA.115.06461

Masamitsu Takahashi, Takahiro Saito, Miyabi Ito, Chiharu Tsukada, Yuki Katono, Hiroki Hosono, Masamitsu Maekawa, Miki Shimada, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, and Masahiro Hiratsuka:
Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation.
Pharmacogenomics J., 15, 26-32 (2015).
DOI: 10.1038/tpj.2014.30

Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M. :
Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.
Int J Clin Oncol., 20(1), 117-25 (2015).
DOI: 10.1007/s10147-014-0699-x

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