薬剤部の研究

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業績

 

2006年

Takashi Iida, Genta Kakiyama, Yohei Hibiya, Shohei Miyata, Takehiko Inoue, Kohsaku Ohno, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara and Alan F. Hofmann:
Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds: Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.
Steroids, 71, 18-29 (2006).
DOI: 10.1016/j.steroids.2005.07.008

Masayuki Ando, Tohru Kaneko, Ritsuko Watanabe, Satoshi Kikuchi, Takaaki Goto, Takashi Iida, Takanori Hishinuma, Nariyasu Mano and Junichi Goto:
High sensitive analysis of rat serum bile acids by liquid chromatography/electrospray ionization tandem mass spectrometry.
J. Pharm. Biomed. Anal., 40, 1179-1186 (2006).
DOI: 10.1016/j.jpba.2005.09.013

Nariyasu Mano, Masaru Mori, Masayuki Ando, Takaaki Goto and Junichi Goto:
Ionization of unconjugated, glycine- and taurine-conjugated bile acids by electrospray ionization mass spectrometry.
J. Pharm. Biomed. Anal., 40, 1231-1234 (2006).
DOI: 10.1016/j.jpba.2005.09.012

Kaoru Murata,Nariyasu Mano and Naoki Asakawa:
Development of a large-volume, membrane-based injection system for gradient elution micro-liquid chromatography.
J. Chromatogr. A, 1106, 146-151 (2006).
DOI: 10.1016/j.chroma.2005.09.047

Genta Kakiyama, Shoujiro Ogawa, Takashi Iida, Yasuo Fujimoto, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Nuclear magnetic resonance spectroscopy of 3β,7β-dihydroxy-5-cholen-24-oic acid multi-conjugates: unusual bile acid metabolites in human urine.
Chem. Phys. Lipids, 140, 48-54 (2006).
DOI: 10.1016/j.chemphyslip.2006.01.003

Nariyasu Mano, Kohei Abe and Junichi Goto:
Immunoaffinity extraction of a peptide modified by a small molecule.
Anal. Biochem., 349, 254-261 (2006).
DOI: 10.1016/j.ab.2005.11.025

Norihiro Kobayashi, Keiichi Iwakami, Shuhei Kotoshiba, Toshifumi Niwa, Yoshinori Kato, Nariyasu Mano and Junichi Goto:
Immunoenzymometric assay for a small molecule, 11-deoxycortisol, with attomole-range sensitivity employing an scFv-enzyme fusion protein and anti-idiotype antibodies.
Anal. Chem., 78, 2244-2253 (2006).
DOI: 10.1021/ac051858f

Hiroaki Yamaguchi, Masahiro Okada, Shou Akitaya, Hiroshi Ohara, Tsuyoshi Mikkaichi, Haruna Ishikawa, Mayumi Sato, Masaki Matsuura, Toshihide Saga, Michiaki Unno, Takaaki Abe, Nariyasu Mano, Takanori Hishinuma and Junichi Goto:
Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.
J. Lipid Res., 47, 1196-1202 (2006).
DOI: 10.1194/jlr.M500532-JLR200

Genta Kakiyama, Atsuko Hosoda, Takashi Iida, Yasuo Fujimoto, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
A direct method for the separation and quantification of bile acid acyl glycosides by high-performance liquid chromatography with an evaporative light scattering detector.
J. Chromatogr. A, 1125, 112-116 (2006).
DOI: 10.1016/j.chroma.2006.05.037

Nariyasu Mano, Mio Kamota, Yusuke Inohara, Shin-ichi Yamaguchi and Junichi Goto:
Analysis of the modification site in a small molecule-modified peptide by ion trap/time-of-flight hybrid mass spectrometry.
Anal. Bioanal. Chem., 386, 682-688 (2006).
DOI: 10.1007/s00216-006-0696-7

Nariyasu Mano, Koichi Sato and Junichi Goto:
Specific affinity extraction method for small molecule-binding proteins.
Anal. Chem., 78, 4668-4675 (2006).
DOI: 10.1021/ac060213s

Kaoru Murata, Nariyasu Mano, Naoki Asakawa and Yasushi Ishihama:
Simplified gradient generator for micro- and nano-liquid chromatography.
J. Chromatogr. A, 1123, 47-52 (2006).
DOI: 10.1016/j.chroma.2006.05.004

Genta Kakiyama, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Lee R. Hagey, Claudio D. Schteingart and Alan F. Hofmann:
Identification of a novel bile acid in swans, tree ducks, and geese: 3α,7α,15α-trihydroxy-5β-cholan-24-oic acid.
J. Lipid Res., 47, 1551-1558 (2006).
DOI: 10.1194/jlr.M600149-JLR200

Masanao Kyuuma, Kazu Kikuchi, Katsuhiko Kojima, Yuriko Sugawara, Mariko Sato, Nariyasu Mano, Junichi Goto, Toshikazu Takeshita, Akitsugu Yamamoto, Kazuo Sugamura and Nobuyuki Tanaka:
AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/Late endosomes.
Cell Struct. Funct., 31, 159-172 (2006).

Tomoko Mizuno, Masaaki Aoki, Yuko Shimada, Midori Inoue, Kumi Nakaya, Toshiaki Takahashi, Yasuto Itoyama, Motoyori Kanazawa, Atsushi Utsumi, Yuka Endo, Taisuke Nomura, Masahiro Hiratsuka, Michinao Mizugaki, Junichi Goto, Michio Hongo and Shin Fukudo:
Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.
J. Psychosomatic Res., 60, 91-97 (2006).

Yoshihisa Tomioka, Shigeki Kisara, Saki Yoshizawa, Mika Ozawa, Naoto Suzuki, Hiroaki Yamaguchi, Takanori Hishinuma, Michinao Mizugaki and Junichi Goto:
Preparation of neocarzinostatin apoprotein mutants and the randomized library on the chromophore-binding cavity.
Biol. Pharm. Bull., 29, 1010-1014 (2006).

Kiyotaka Usui, Takanori Hishinuma, Hiroaki Yamaguchi, Naoki Tachiiri and Junichi Goto:
Determination of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) using LC-ESI-MS method and application to hemolyzed blood.
J. Chromatogr. B, 831, 105-109 (2006).

Naoto Suzuki, Takanori Hishinuma, Hiroaki Yamaguchi, Mayumi Sato, Tohru Kaneko, Masaki Matsuura, Tomoko Kaminishi, Hironori Nakamura, Mika Ozawa, Yoshihisa Tomioka and Junichi Goto:
Simple and sensitive determination of sirolimus in whole blood by liquid chromatography/electrospray ionization tandem mass spectrometry (J).
Jap. J. Pharm. Health Care Sci., 32, 289-294 (2006).

Naoto Nakagawa, Kaori Narahara, Etsuko Ishikawa, Hitomi Frudate, Fumi Yabuta, Hidehisa Tasaka, Kyoko Inooka, Ayako Zenda, Kanehiko Hisamichi, Yukinaga Kishikawa, Hitoshi Nakamura, Yuriko Murai, Takanori Hishinuma and Junichi Goto:
Pharmacotherapy interventions by pharmacists increase medication safety in ophthalmology patients – Ophthalmologists improve therapy after drug therapy problems identified (J).
Jap. J. Pharm. Health Care Sci., 32, 747-753 (2006).

Hiroaki Yamaguchi, Takanori Hishinuma, Naomi Endo, Hiroki Tsukamoto, Yukinaga Kishikawa, Mayumi Sato, Yuriko Murai, Masahiro Hiratsuka, Kiyoshi Ito, Chikako Okamura, Nobuo Yaegashi, Naoto Suzuki, Yoshihisa Tomioka and Junichi Goto:
Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.
Int. J. Gynecol. Cancer, 16, 979-985 (2006).

Kiyotaka Usui, Takanori Hishinuma, Hiroaki Yamaguchi, Toshihide Saga, Toshihiro Wagatsuma, Kunihiko Hoshi, Naoki Tachiiri, Kuniaki Miura and Junichi Goto:
Simultaneous determination of pancuroniumu, vecuronium and their related compounds using LC/ESI-MS.Leg. Med. (Tokyo), 8, 166-171 (2006).

M. Miyata, H. Watase, W. Hori, M.Shimada, K. Nagata, F. J. Gonzalez and Y. Yamazoe:
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.
Xenobiotica, 36, 631-644 (2006).

Masaaki Miyata, Yoshiki Matsuda, Hiroyuki Tsuchiya, Hirotaka Kitada, Takanori Akase, Miki Shimada, Kiyoshi Nagata, Frank J. Gonzalez and Yasushi Yamazoe:
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.
Drug Metabol. Pharmacokin., 21, 315-323 (2006).

Wachiraporn Noracharttiyapot, Yoko Nagai, Tsutomu Matsubara, Masaaki Miyata, Miki Shimada, Kiyoshi Nagata and Yasushi Yamazoe:
Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction.
Drug Metabol. Pharmacokin., 21, 99-108 (2006).

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