薬剤部の研究

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業績

 

2002年

Nariyasu Mano, Koji Nishimura, Takashi Narui, Shigeo Ikegawa and Junichi Goto:
Characterization of rat liver bile acid acyl glucuronosyltransferase.
Steroids, 67, 257-262 (2002).

Takashi Iida, Ryusei Nakamori, Rie Yabuta, Satoru Yada, Yuzuru Takagi, Nariyasu Mano, Shigeo Ikegawa, Junichi Goto and Toshio Nambara:
Potential bile acid metabolites. 24. An efficient synthesis of carboxyl-linked glucosides and their chemical properties.
Lipids, 37, 101-110 (2002).

Toshiaki Kume, Naoki Asai, Hiroyuki Nishikawa, Nariyasu Mano, Taro Terauchi, Ryota Taguchi, Hisashi Shirakawa, Fumitaka Osakada, Hiroki Mori, Naoki Asakawa, Masahiro Yonaga, Yukio Nishizawa, Hachiro Sugimoto, Shun Shimohama, Hiroshi Katsuki, Shuji Kaneko and Akinori Akaike:
Isolation of a diterpenoid substance with potent neuroprotective acitivity from fetal calf serum.
Proc. Natl. Acad. Sci. USA, 99, 3288-3293 (2002).
DOI: www.pnas.org/cgi/doi/10.1073/pnas.052693999

Nariyasu Mano, Takashi Narui, Ayako Nikaido and Junichi Goto:
Separation and determination of diastereomeric flurbiprofen acyl glucuronides in human urine by LC/ESI-MS with a simple column-switching technique.
Drug Metabol. Pharmacokin., 17, 142-149 (2002).

Nariyasu Mano, Ayako Nikaido, Takashi Narui, Daisuke Yamasaki and Junichi Goto:
Rapid and simple quantitative assay method for diastereomeric flurbiprofen glucuronides in the incubation mixture.
J. Chromatogr. B, 776, 125-131 (2002).

Takashi Iida, Masahiro Hikosaka, Genta Kakiyama, Keisuke Shiraishi, Claudio D. Schteingart, Lee R. Hagey, Huong-Thu Ton-Nu, Alan F. Hofmann, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3α,7α,16- and 3α,7α,15-trihydroxy-5β-cholan-24-oic-acids.
Chem. Pharm. Bull., 50, 1327-1334 (2002).
DOI: 10.1002/mrc.1173

Norihiro Kobayashi, Hiroshi Katsumata, Yoshiaki Uto, Junichi Goto, Toshifumi Niwa, Koju Kobayashi and Yoshiaki Mizuuchi:
A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test.
Steroids, 67, 827-833 (2002).

Norihiro Kobayashi, Kana Shibahara, Kayo Ikegashira, Kazuki Shibusawa and Junichi Goto:
Single-chain Fv fragments derived from an anti 11-deoxycortisol antibody: Affinity, specificity, and idiotype analysis.
Steroids, 67, 733-742 (2002).

Masahiro Hiratsuka, Yukinaga Kishikawa, Yoh Takekuma, Masaki Matsuura, Kaori Narahara, Samar Ismail Hamdy, Naomi Endo, Junichi Goto and Michinao Mizugaki:
Genotyping of the N-acetyltransferase2 polymorphism in the prediction of adverse drug reactions to isoniazid in Japanese patients.
Drug Metabol. Pharmacokin., 17 (4), 357-362 (2002).

Sookie La, Sungyeon Ahn, Jung-Han Kim, Junichi Goto, One-Kyun Choi and Kyoug-Rae Kim:
Enantioseparation of chiral aromatic amino acids by capillary electrophoresis in dual-cyclodextrin selector modes.
Electrophoresis, 23, 4123-4131 (2002).

Takashi Iida, Rie Yabuta, Junichi Goto and Toshio Nambara:
Direct capillary gas chromatographic analysis and thermal stability of carboxy-linked glucosides of bile acids.
Chromatographia, 2002, 56, 489-494.

Norihiro Kobayashi, Pi Sun, Yayoi Fujimaki, Toshifumi Niwa, Tadashi Nishio, Junichi Goto and Hiroshi Hosoda:
Generation of a novel monoclonal antibody against cortisol-[C-4]-bovine albumin conjugate. Application to enzyme-linked immunosorbent assay for urinary and serum cortisol.
Anal. Sci., 18, 1309-1314 (2002).

Wataru Honma, Miki Shimada, Hironobu Sasano, Shogo Ozawa, Masaaki Miyata, Kiyoshi Nagata, Toshihiko Ikeda, and Yasushi Yamazoe:
Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver.
Drug Metab. Dispos., 30, 944-949 (2002).

Miki Shimada, Yoshiteru Kamiyama, Akira Sato, Wataru Honma, Kiyoshi Nagata, and Yasiishi Yamazoe:
A hydroxysteroid sulfotransferase, St2b2, is a skin cholesterol sulfotransferase in mice.
J. Biochem., 131, 167-169 (2002).

Masayuki Furukawa, Takayuki Okubo, Makoto Ogino, Toru Yamazaki, Miki Shimada, Kiyoshi Nagata2 and Yasushi Yamazoe:
Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation.
J. Biochem., 131, 71-78 (2002).

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