薬剤部の研究

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業績

 

2007年

Takaaki Goto, Khin Than Myint, Koichi Sato, Osamu Wada, Genta Kakiyama, Takashi Iida, Takanori Hishinuma, Nariyasu Mano and Junichi Goto:
LC/ESI-tandem mass spectrometric determination of bile acid 3-sulfates in human urine. 3β-Sulfooxy-12α-hydroxy-5β-cholanoic acid is an abundant nonamidated sulfate.
J. Chromatogr. B, 846, 69-77 (2007).
DOI: 10.1016/j.jchromb.2006.08.013

Takashi Iida, Shoujiro Ogawa, Keiji Hosoi, Mitsuko Makino, Yasuo Fujimoto, Takaaki Goto, Nariyasu Mano, Junichi Goto and Alan F. Hofmann:
Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: Osmiumporphyrin complex/tert-butyl hydroperoxide system.
J. Org. Chem., 72, 823-830 (2007).
DOI: 10.1021/jo061800g

Shoko Okazaki, Tsuyoshi Tachibana, Akira Naganuma, Nariyasu Mano and Shusuke Kuge:
Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal.
Mol. Cell, 27, 675-688 (2007).
DOI: 10.1016/j.molcel.2007.06.035

Genta Kakiyama, Hideyuki Tamegai, Takashi Iida, Kuniko Mitamura, Shigeo Ikegawa, Takaaki Goto, Nariyasu Mano, Junichi Goto, Peter Holz, Lee R. Hagey and Alan F. Hofmann:
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15α-hydroxylithocholic acid.
J. Lipid Res., 48, 2682-2692 (2007).
DOI: 10.1194/jlr.M700340-JLR200

Masahiro Nomoto , Masaaki Miyata, Miki Shimada, Kouichi Yoshinari, Frank J Gonzalez, Shigeki Shibasaki, Tohru Kurosawa, Yasuhiro Shindo, Yasushi Yamazoe:
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output.
European Journal of Pharmacology 574,192-200 (2007).

Takanori Hishinuma, Kaori Suzuki, Masayoshi Saito, Hiroaki Yamaguchi, Naoto Suzuki, Yoshihisa Tomioka, Izumi Kaneko, Masao Ono and Junichi Goto:
Simultaneous quantification of seven prostanoids using liquid chromatography/tandem mass spectrometry: The effects of arachidonic acid on prostanoid production in mouse bone marrow-derived mast cells.
Prostaglandins Leukot. Essent. Fatty Acids, 76, 321-329 (2007).

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