薬剤部の研究

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業績

 

2010年

Jun Hosogi, Hideyuki Tanaka, Kazuhiro Fujita, Takashi Kuwabara, Shigeo Ikegawa, Norihiro Kobayashi, Nariyasu Mano and Junichi Goto:
LC-MS/MS coupled with immunoaffinity extraction for determination of estrone, 17β-estradiol and estrone 3-sulfate in human plasma.
J. Chromatogr. B, 878, 222-227 (2010).
DOI: 10.1016/j.jchromb.2009.08.010

Rika Okihara, Kuniko Mitamura, Maki Hasegawa, Megumi Mori, Akina Muto, Genta Kakiyama, Shoujiro Ogawa, Takashi Iida, Miki Shimada, Nariyasu Mano, and Shigeo Ikegawa:
Potential corticoid metabolites: Chemical synthesis of 3- and 21-monosulfates and their double-conjugates of tetrahydrocorticosteroids in the 5α- and 5β-series.
Chem. Pharm. Bull., 58, 344-353 (2010).

Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Mitsuru Kobayashi, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, and Yutaka Imai:
Practice and awareness of physicians regarding home blood pressure measurement in Japan.
Hypertens. Res., 33, 428-434 (2010).
DOI: 10.1038/hr.2010.10

Lee R. Hagey, Takashi Iida, Hideyuki Tamegai, Shoujiro Ogawa, Mizuho Une, Kiyoshi Asahina, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Matthew D. Krasowski, and Alan F. Hofmann:
Major biliary bile acids of the Medaka (Oryzias latipes): 25R- and 25S-epimers of 3α,7α,12α-trihydroxy-5β-cholestanoic acid.
Zoo. Sci., 27, 565-573 (2010).
DOI: 10.2108/zsj.27.565

Hiroshi Ohara, Rumiko Saito, Satoshi Hirakawa, Miki Shimada, Nariyasu Mano, Ryuhei Okuyama, and Setsuya Aiba:
Gene expression profiling defines the role of ATP-exposed keratinocytes in skin inflammation.
J. Dermatol. Sci., 58, 143-151 (2010).
DOI: 10.1016/j.jdermsci.2010.02.007

Hiroaki Yamaguchi, Misa Sugie, Masahiro Okada, Tsuyoshi Mikkaichi, Takafumi Toyohara, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, and Nariyasu Mano:
Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.
Drug Metab. Pharmacokinet., 25, 314-317 (2010).

Shoujiro Ogawa, Yuuki Adachi, Genta Kakiyama, Miki Shimada, Nariyasu Mano, Junichi Goto, and Takashi Iida:
Chemical synthesis of (22E)-3α,6α,7α,12α-tetrahydroxy-5β-chol-22-en-24-oic acid and its N-acylamidated conjugates with glycine or taurine: Precursors of the [22,23-3H] labelled tracers.
Chem. Pharm. Bull., 58, 1103-1106 (2010).

Masaru Mori, Kohei Abe, Hiroaki Yamaguchi, Junichi Goto, Miki Shimada, and Nariyasu Mano:
Production of 18O-single labeled peptide fragments during trypsin digestion of proteins for quantitative proteomics using nanoLC-ESI-MS/MS.
J. Proteome Res., 9, 3741-3749 (2010).
DOI: 10.1021/pr900865p

Mitsuru Kobayashi, Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Michihiro Satoh, Hirohito Metoki,Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, and Yutaka Imai:
Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan.
Hypertens. Res., 33, 960-964 (2010).
DOI: 10.1038/hr.2010.89

Masafumi Kikuchi, Yasunori Yaoita, Nariyasu Mano, and Masao Kikuchi:
Glycosides from the leaves of Syringa vulgaris and their growth inhibitory activity against human cancer cell lines.
Shoyakugaku zasshi, 64, 104-105 (2010).

Wataru Sato, Hiroyuki Suzuki, Takamitsu Sasaki, Takeshi Kumagai, Shuhei Sakaguchi, Michinao Mizugaki, Shinichi Miyairi, Yasushi Yamazoe, and Kiyoshi Nagata:
Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable-derived cell line using a dual reporter plasmid.
Drug Metab. Pharmacokinet. 25 (2), 180-189 (2010).

Hiroyuki Suzuki, Takamitsu Sasaki, Takeshi Kumagai, Shuhei Sakaguchi, and Kiyoshi Nagata:
Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs).
J. Toxicol. Sci., 35, 137-147 (2010).

Tomoyuki Oe, Masamitsu Maekawa, Ryo Satoh, Seon Hwa Lee and Takaaki Goto:
Combining [13C6]-phenylisothiocyanate and the Edman degradation reaction:
a possible breakthrough for absolute quantitative proteomics together with protein identification.
Rapid Commun. Mass Spectrom., 24, 173-179 (2010).

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