薬剤部の研究

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業績

 

2004年

Nariyasu Mano, Takaaki Goto, Masashi Uchida, Koji Nishimura, Masayuki Ando, Norihiro Kobayashi and Junichi Goto:
Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain.
J. Lipid Res., 45, 295-300 (2004).
DOI: 10.1194/jlr.M300369-JLR200

Genta Kakiyama, Takashi Iida, Atsushi Yoshimoto, Takaaki Goto, Nariyasu Mano, Junichi Goto, Toshio Nambara, Lee R. Hagey and Alan F. Hofmann:
Chemical synthesis of (22E)-3α,6β,7β-trihydroxy-5β-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat.
J. Lipid Res., 45, 567-573 (2004).
DOI: 10.1194/jlr.D300027-JLR200

Nariyasu Mano, Yoko Nagaya, Shuntaro Saito, Norihiro Kobayashi and Junichi Goto:
Analysis of the antigen binding site of anti-deoxycholate monoclonal antibody using a novel affinity labeling reagent, acyl adenylate.
Biochemistry, 43, 2041-2048 (2004).
DOI: 10.1021/bi035855d

Shoujiro Ogawa, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
The remote-oxyfunctionalization of unactivated carbons in (5β)-3-oxobile acids by 2,6-dichloropyridine N-oxide catalyzed by ruthenium-porphyrin and HBr: a direct lactonization at C-20.
Org. Biomol. Chem., 2, 1013-1018 (2004).

Genta Kakiyama, Takashi Iida, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Synthesis of 3α,7α,14α-trihydroxy-5β-cholan-24-oic acid: A potential primary bile acid in vertebrates.
Chem. Pharm. Bull., 52, 371-374 (2004).

Eiichi Yamamoto, Takahisa Sakaguchi, Takashi Kajima, Nariyasu Mano and Naoki Asakawa:
Novel methylcellulose-immobilized ion-exchange precolumn for on-line enrichment of cationic drugs in plasma.
J. Chromatogr. B, 807, 327-334 (2004).
DOI: 10.1016/j.jchromb.2004.04.028

Nariyasu Mano, Yoshiaki Sato, Masanori Nagata, Takaaki Goto and Junichi Goto:
Bioconversion of 3β-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems.
J. Lipid Res., 45, 1741-1748 (2004).
DOI: 10.1194/jlr.M400157-JLR200

Takashi Iida, Shoujiro Ogawa, Shouhei Miyata, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Biomimetic oxidation of unactivated carbons in steroids by a model of cytochrome P-450, oxorutheniumporphyrinate complex.
Lipids, 39, 873-880 (2004).

Takaaki Goto, Akihiro Shibata, Takashi Iida, Nariyasu Mano and Junichi Goto:
Sensitive mass spectrometric detection of neutral bile acid metabolites. Formation of adduct ions with an organic anion in atmospheric pressure chemical ionization.
Rapid Commun. Mass Spectrom., 18, 2360-2364 (2004).
DOI: 10.1002/rcm.1630

Nariyasu Mano, Kie Kasuga, Norihiro Kobayashi and Junichi Goto:
A nonenzymatic modification of the amino-terminal domain of histone H3 by bile acid acyl adenylate.
J. Biol. Chem., 279, 55034-55041 (2004).
DOI: 10.1074/jbc.M409205200

Takashi Iida, Shoujiro Ogawa, Genta Kakiyama, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Capillary gas chromatographic separation of bile acid acyl glycosides without thermal decomposition and isomerization.
J. Chromatogr. A, 1057, 171-176 (2004).
DOI: 10.1016/j.chroma.2004.09.029

Mitsunobu Okuyama, Norihiro Kobayashi, Wakako Takeda, Takako Anjo, Yasuhiko Matsuki, Junichi Goto, Akira Kambegawa and Shinjiro Hori:
Enzyme-Linked Immunosorbent assay for monitoring toxic dioxin congeners in milk based on a newly generated monoclonal anti-dioxin antibody.
Anal. Chem., 76, 1948-1956 (2004).

Tsuyoshi Mikkaichi, Takehiro Suzuki, Tohru Onogawa, Masayuki Tanemoto, Hiroya Mizutamari, Masahiro Okada, Tatsuji Chaki, Satohiro Masuda, Taro Tokui, Nobuaki Eto, Michiaki Abe, Fumitoshi Satoh, Michiaki Unno, Takanori Hishinuma, Ken-ichi Inui, Sadayoshi Ito, Junichi Goto and Takaaki Abe:
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
Proc. Natl. Acad. Sci. USA., 101, 3569-3574 (2004).

Naoto Suzuki, Takanori Hishinuma, Satoko Chiba, Toshihide Saga, Hiroki Tsukamoto, Michinao Mizugaki and Juncihi Goto:
Quantitative Liquid chromatography-tandem mass spectrometric analysis of 11-dehydroTXB2 in the urine.
Prostagrandins Other Lipid Mediat., 73, 103-110 (2004).

Man-Jeong Paik, Yoonsuk Lee, Junichi Goto and Kyoung-Rae Kim:
Chiral discrimination of multiple profens as diastereomeric (R)-(+)-1-phenylethylamines by achiral dual-column gas chromatography.
J. Chromatogr. B, 803, 257-265 (2004).

Hiroki Tsukamoto, Takanori Hishinuma, Naoto Suzuki, Risa Tayama, Masahiro Hiratsuka, Yoshihisa Tomioka, Michinao Mizugaki and Junichi Goto:
Thiazolidinediones increase arachidonic acid release and subsequent prostanoid production in peroxisome proliferator-activated receptor γ-independent manner.
Prostagrandins Other Lipid Mediat., 73, 191-213 (2004).

Hiroki Tsukamoto, Takanori Hishinuma, Risa Tayama, Kaori Narahara, Naoto Suzuki, Yoshihisa Tomioka and Junichi Goto:
The induction of prostaglandin E synthase and upregulation of cyclooxygenase-2 by 9-cis retinoic acid.
Prostagrandins Other Lipid Mediat., 74, 61-74 (2004).

Tomohiro Okuda, Yukiko Ito, Naoto Nakagawa, Takanori Hishinuma, Hiroki Tsukamoto, Kentaro Iwabuchi, Takehiko Watanabe, Kiyoyuki Kitaichi, Junichi Goto and Kazuhiko Yanai:
Drug interaction between methamphetamine and antihistamines: Behavioral changes and concentrations of methamphetamane in rats.
Eur. J. Pharmacol., 505, 135-144 (2004).

Miki Shimada, Reiko Terazawa, Yoshiteru Kamiyama, Wataru Honma, Kiyoshi Nagata, and Yasushi Yamazoe:
Unique Properties of a Renal Sulfotransferase, St1d1, in Dopamine Metabolism.
J. Pharmacol. Exp. Ther., 310, 808-814. (2004).

T. Matsubara, H. J. Kim, M. Miyata, M.Shimada, K. Nagata and Y. Yamazoe:
Isolation and characterization of a new major interestinal CYP3A form, CYP3A62, in the rat.
J. Pharmacol. Exp. Ther., 309, 1282-1290. (2004)

Tomonari Takada, Makoto Ogino, Masaaki Miyata, Miki Shimada, Kiyoshi Nagata and Yasushi Yamazoe:
Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor.
Drug Metabol. Pharmacokin., 19, 103-113. (2004)

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