薬剤部の研究

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業績

 

2019年

Masamitsu Maekawa, Isamu Jinnoh, Aya Narita, Takashi Iida, Daisuke Saigusa, Anna Iwahori, Hiroshi Nittono, Torayuki Okuyama, Yoshikatsu Eto, Kousaku Ohno, Peter T. Clayton,Hiroaki Yamaguchi, and Nariyasu Mano.
Investigation of diagnostic performance of five urinary cholesterol metabolites for Niemann-Pick disease type C.
Journal of Lipid Research, 60(12), 2074-2081 (2019).
DOI: 10.1194/jlr.M093971

Yoshitomi Kanemitsu, Eikan Mishima, Masamitsu Maekawa, Yotaro Matsumoto,
Daisuke Saigusa, Hiroaki Yamaguchi, Jiro Ogura, Hiroki Tsukamoto, Yoshihisa Tomioka, Takaaki Abe, Nariyasu Mano.
Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS.
Scientific Reports, 9 19075 (2019).
DOI: 10.1038/s41598-019-55600-1

Masami Tsuchiya, Taku Obara, Takamasa Sakai, Kaori Nomura, Chizuko Takamura, Nariyasu Mano.
Quality Evaluation of Adverse Drug Reaction Reports Using the Japanese Adverse Drug Event Report (JADER) database.
Pharmacoepidemiology and Drug Safety, in press (2019).

Yukinaga Kishikawa, Miki Sugiyama, Yousuke Nishikawa, Junji Sakurai, Yasuhito Nobushi, Yasuhiro Tsuji, Taku Obara, Fumiaki Ishizawa.
Comparison of drug efficacy and safety for restless legs syndrome: A Meta-analysis.
Journal of Drug Interaction Research, 43(3), 189-198 (2019).

Tanoue K, Nishigori H, Watanabe Z, Tanaka K, Sakurai K, Mizuno S, Ishikuro M, Obara T, Tachibana M, Hoshiai T, Saito M, Sugawara J, Tatsuta N, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N, Metoki H.
Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study.
Journal of Interpersonal Violence, in press (2019).
DOI: 10.1177/0886260519881517

Ryutaro Arita, Takehiro Numata, Shin Takayama, Taku Obara, Akiko Kikuchi,
Minoru Ohsawa, Akifumi Suzuki, Takashi Yokota, Mizue Kusaba, Nobuo Yaegashi, and Tadashi Ishii.
Responder analysis of daikenchuto treatment for constipation in post-stroke patients: A subanalysis of a randomized control trial.
Journal of Evidence-Based Integrative Medicine, in press (2019).

Masamitsu Maekawa, Isamu Jinnoh, Yotaro Matsumoto, Aya Narita, Ryuichi Mashima, Hidenori Takahashi, Anna Iwahori, Daisuke Saigusa, Kumiko Fujii, Ai Abe, Katsumi Higaki, Shosei Yamauchi, Yuji Ozeki, Kazutaka Shimoda, Yoshihisa Tomioka, Torayuki Okuyama, Yoshikatsu Eto, Kousaku Ohno, Peter T Clayton, Hiroaki Yamaguchi and Nariyasu Mano.
Structural Determination of Lysosphingomyelin-509 and Discovery of Novel Class Lipids from Patients with Niemann?Pick Disease Type C.
International Journal of Molecular Sciences, 20(20), 5018 (2019).
DOI: 10.3390/ijms20205018

Hiroki Tsukamoto, Kanae Kubota, Ayumi Shichiku, Masamitsu Maekawa, Nariyasu Mano, Hideo Yagita, Shoichiro Ohta and Yoshihisa Tomioka.
An agonistic anti-Toll-like receptor 4 monoclonal antibody as an effective adjuvant for cancer immunotherapy.
Immunology,158(2), 136-149 (2019).
DOI: 10.1111/imm.13095

Masafumi Kikuchi, Kensuke Shigeta, Masaki Tanaka, Shinya Takasaki, Miki Akiba, Hisashi Oishi, Tetsu Sado, Yasushi Matsuda, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi.
Estimation of blood sirolimus concentration based on tacrolimus concentration/dose normalized by body weight ratio in lung transplant patients.
Therapeutic Drug Monitoring, 41(5), 615-619 (2019).
DOI: 10.1097/FTD.0000000000000649.

Yasuko Ikeda-Sakai, Yoshiyuki Saito, Taku Obara, Mikako Goto, Tami Sengoku, Yoshimitsu Takahashi, Hiromi Hamada, Takeo Nakayama, Atsuko Murashima.
Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs
During Pregnancy in Japan: A Cross-Sectional Study.
Scientific Reports, in press (2019).

Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa.
Reduced sleep efficiency measured using an objective device was related with an increased prevalence of home hypertension in Japanese adults.
Hypertension Research, in press (2019).

Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa.
The multiple measurements of urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study.
Hypertension Research, in press (2019).

Tanaka M, Kikuchi M, Takasaki S, Hirasawa T, Sigeta K, Noda A, Akiba M, Matsuda Y, Oishi H, Sado T, Noda M, Okada Y, Mano N, Yamaguchi H.
Limited sampling strategy for the estimation of mycophenolic acid and its acyl glucuronide metabolite area under the concentration-time curve in Japanese lung transplant recipients.
Journal of Pharmacy & Pharmaceutical Sciences, 22(1), 407-417 (2019).
DOI: 18433/jpps30505.

Aoi Noda, Taku Obara, Kazuki Takada, Yukinaga Kishikawa, Shinya Abe, Shoko Yoshimachi, Nariyasu Mano, Yutaka Imai, Teruaki Goto.
Changes in community pharmacists’ knowledge, attitudes, and practice regarding the management of hypertension before and after educational interventions.
Clinical and Experimental Hypertension, in press (2019).

Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki.
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization.
BMC Medical Education, in press (2019).

Michihiro Satoh, Hirohito Metoki, Kei Asayama, Takahisa Murakami, Ryusuke Inoue, Megumi Tsubota‐Utsugi, Ayako Matsuda, Takuo Hirose, Azusa Hara, Taku Obara, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo.
Age‐Related Trends in Home Blood Pressure, Home Pulse Rate, and Day‐to‐Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study.
Journal of the American Heart Association, in press (2019).

Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Masato Nagai, Keiko Murakami, Aoi Noda, Masahiro Kikuya, Shigeo Kure, Shinichi Kuriyama.
Effectiveness of Seasonal Inactivated Influenza Vaccination in Japanese Schoolchildren: An Epidemiologic Study at the Community Level.
Human Vaccines & Immunotherapeutics, in press (2019).

Masamitsu Maekawa, Taku Tsukamoto, Shinya Takasaki, Masafumi Kikuchi, Yu Sato, Jiro Ogura, Yoshihiro Hayakawa, Hiroaki Yamaguchi, Nariyasu Mano.
Fundamental study of behaviors of in-source collision induced dissociation and shifting the linear range of calibration curves of various drugs and the metabolites used for therapeutic drug monitoring.
Chromatography, 40(2), 71-78 (2019).
DOI: 10.15583/jpchrom.2019.009

Takahiro Suga, Hiroaki Yamaguchi, Jiro Ogura, Saori Shoji, Masamitsu Maekawa, Nariyasu Mano.
Altered bile acid composition and disposition in a mouse model of nonalcoholic steatohepatitis.
Toxicology and Applied Pharmacology, 379 in press (2019).
DOI: 10.1016/j.taap.2019.114664

Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, Sugawara J, Tamiya G, Hozawa A, Nakaya N, Tsuchiya N, Nakamura T, Narita N, Kogure M, Hirata T, Tsuji I, Nagami F, Fuse N, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Suzuki Y, Osumi N, Nakayama K, Ito K, Egawa S, Chida K, Kodama E, Kiyomoto H, Ishii T, Tsuboi A, Tomita H, Taki Y, Kawame H, Suzuki K, Ishii N, Ogishima S, Mizuno S, Takai-Igarashi T, Minegishi N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Tanabe O, Koshiba S, Hashizume H, Motohashi H, Tominaga T, Ito S, Tanno K, Sakata K, Shimizu A, Hitomi J, Sasaki M, Kinoshita K, Tanaka H, Kobayashi T, the Tohoku Medical Megabank Project Study Group, Kure S, Yaegashi N, Yamamoto M.
Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective.
International Journal of Epidemiology, in press (2019).

Kuniyoshi Y, Kikuya M, Miyashita M, Yamanaka C, Ishikuro M, Obara T, Metoki H, Nakaya N, Nagami F, Tomita H, Hozawa A, Tsuji I, Kure S, Yaegashi N, Kuriyama S.
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study.
Disaster medicine and public health preparedness, in press.
DOI: 10.1017/dmp.2019.8.

Hattori H, Kitamura A, Takahashi F, Kobayashi N, Sato A, Miyauchi N, Nishigori H, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Kuriyama S, Metoki H, Yaegashi N, Nakai K, Arima T; Japan Environment and Children’s Study Group.
The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study.
Reproductive biology and endocrinology, 17(1), 27 (2019).
DOI: 10.1186/s12958-019-0471-1

Kuniyoshi Y, Kikuya M, Matsubara H, Ishikuro M, Obara T, Kure S, Kuriyama S.
Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake.
Breastfeeding Medicine, in press.
DOI: 10.1089/bfm.2018.0254.

Sugawara J, Ochi D, Yamashita R, Yamauchi T, Saigusa D, Wagata M, Obara T, Ishikuro M, Tsunemoto Y, Harada Y, Shibata T, Mimori T, Kawashima J, Katsuoka F, Igarashi-Takai T, Ogishima S, Metoki H, Hashizume H, Fuse N, Minegishi N, Koshiba S, Tanabe O, Kuriyama S, Kinoshita K, Kure S, Yaegashi N, Yamamoto M, Hiyama S, Nagasaki M.
Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy.
BMJ Open, 9(2), e025939 (2019).
DOI: 10.1136/bmjopen-2018-025939

Tanaka K, Nishigori H, Watanabe Z, Iwama N, Satoh M, Murakami T, Hamada H, Hoshiai T, Saito M, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N, Metoki H; and Japan Environment & Children’s Study Group.
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study.
Hypertension Research, 42(4), 558-566 (2019).
DOI: 10.1038/s41440-019-0206-x

Nishigori H, Obara T, Nishigori T, Metoki H, Mizuno S, Ishikuro M, Sakurai K, Hamada H, Watanabe Z, Hoshiai T, Arima T, Nakai K, Kuriyama S, Yaegashi N; Miyagi Regional Center of Japan Environment & Children’s Study Group.
The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study.
Journal of maternal-fetal and neonatal medicine, in press.
DOI: 10.1080/14767058.2018.1560415

Watanabe Z, Nishigori H, Tanoue K, Tanaka K, Iwama N, Satoh M, Murakami T, Nishigori T, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Saito M, Tachibana M, Fujiwara I, Arima T, Takeda T, Kuriyama S, Nakai K, Yaegashi N, Metoki H; Japan Environment & Children's Study Group.
Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study.
Journal of Affective Disorders, 245, 475-483 (2019).
DOI: 10.1016/j.jad.2018.11.061

Iwama N, Metoki H, Nishigori H, Mizuno S, Takahashi F, Tanaka K, Watanabe Z, Saito M, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Sugiyama T, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N; Japan Environment & Children’s Study Group.
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study.
Hypertension Research, 42(1), 85-94 (2019).
DOI: 10.1038/s41440-018-0124-3

Iwama N, Metoki H, Nishigori H, Mizuno S, Takahashi F, Tanaka K, Watanabe Z, Saito M, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Sugiyama T, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N; Japan Environment & Childrenʼs Study Group.
Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study.
Journal of Hypertension, 37(1), 206-215 (2019).
DOI: 10.1097/HJH.0000000000001846

Tomonori Kobayashi, Aoi Noda, Taku Obara, Masami Tsuchiya, Kazutoshi Akasaka, Makiko Yoshida, Masaki Matsuura, Mayumi Sato, Yuriko Murai, Hiroaki Yamaguchi, Fumito Tsuchiya, Kenji Kihira, Nariyasu Mano.
Knowledge, Attitudes, and Practice of Hospital Pharmacists regarding Pharmacovigilance and Adverse Drug Reaction Reporting in Japan.
Hospital Pharmacy, in press (2019).

Makiko Yoshida, Taku Obara, Saya Kikuchi, Michihiro Satoh, Yoshihiko Morikawa, Nobuhiro Ooba, Hiroaki Yamaguchi, Nariyasu Mano.
Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015.
Journal of attention disorders, 24(2),175-191(2020).
DOI: 10.1177/1087054719843179.

Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe.
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Nat. Commun., 10(1), 1835 (2019).
DOI: 10.1038/s41467-019-09735-4.

Masamitsu Maekawa, Aya Narita, Isamu Jinnoh, Takashi Iida, Thorsten Marquardt, Eugen Mengel, Yoshikatsu Eto, Peter T Clayton, Hiroaki Yamaguchi, and Nariyasu Mano.
Diagnostic performance evaluation of sulfate-conjugated cholesterol metabolites as urinary biomarkers of Niemann–Pick disease type C.
Clin Chim Acta, 494, 58-63 (2019).
DOI: 10.1016/j.cca.2019.03.1610

Shinya Takasaki, Hiroaki Yamaguchi, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Akihiro Ito, Nariyasu Mano.
Long-term relationship between everolimus blood concentration and clinical outcomes in Japanese patients with metastatic renal cell carcinoma: a prospective study.
J. Pharm. Health. Care. Sci., 5, 6 (2019).
DOI: 10.1186/s40780-019-0135-5

Masami Tsuchiya, Akihisa Esashi, Taku Obara, Kyoko Inooka, Nariyasu Mano, and Chizuko Takamura.
Effect of educational interventions on adverse drug reaction reporting in a cancer institute in Japan: A questionnaire study.
Hosp. Pharm., 54, 93-99 (2019).
DOI: 10.1177/0018578718769242

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Kasumi Sakurai, Tetsuo Hoshiai, Masatoshi Saito, Ikuma Fujiwara, Takahir Arima, Kunihiko Nakai, Shinichi Kuriyama, Nariyasu Mano, Hirohito Metoki, Nobuo Yaegashi, and Japan Environment & Children’s Study Group.
Preconception folic acid supplementation use and the occurrence of neural tube defect in Japan. A nationwide birth cohort study of the Japan Environment and Children’s Study.
Congenit. Anom., in press.
DOI: 10.1111/cga.12293

Tomonori Sato, Yoshihide Kawasaki, Masamitsu Maekawa, Shinya Takasaki, Daisuke Saigusa, Hideki Ota, Shuichi Shimada, Shinichi Yamashita, Koji Mitsuzuka, Hiroaki Yamaguchi, Akihiro Ito, Kengo Kinoshita, Seizo Koshiba, Nariyasu Mano, and Yoichi Arai.
Value of global metabolomics in association with diagnosis and clinicopathological factors of rl cell carcinoma.
Int. J. Cancer, in enapress.
DOI: 10.1002/ijc.32115

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Masato Suzuka, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, and Nariyasu Mano.
Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database.
Pharmacoepidemiol. Drug Saf., in press.
DOI: 10.1002/pds.4749

Aoi Noda, Taku Obara, Kazutaka Shinya Abe, Shoko Yoshimachi, Michihiro Satoh, Mami Ishikuro, Azusa Hara, Hirohito Metoki, Nariyasu Mano, Takayoshi Ohkubo, Teruaki Goto, and Yutaka Imai.
The present situation of home blood pressure measurement among outpatients in Japan.
Clin. Exp. Hypertens., in press.
DOI: 10.1080/10641963.2019.1571601

Takahiro Suga, Hiroaki Yamaguchi, Jiro Ogura, and Nariyasu Mano.
Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter α/β.
Biochim. Biophys. Acta Biomembr., in press.
DOI: 10.1016/j.bbamem.2019.03.003

Masamitsu Maekawa, Aya Narita, Isamu Jinnoh, Takashi Iida, Thorsten Marquardt, Rugen Mengel, Hiroaki Yamaguchi, Yoshikatsu Eto, Peter T. Clayton, and Nariyasu Mano.
Diagnostic performance evalution of sulfate-conjugated cholesterol metabolites as urinary biomarkers of Niemann-Pick disease type C.
Clin. Chim. Acta, in press.
DOI: 10.1016/j.cca.2019.03.1610

Masafumi Kikuchi, Kensuke Shigeta, Masaki Tanaka, Shinya Takasaki, Miki Akiba, Hisashi Oishi, Tetsu Sado, Yasushi Matsuda, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, and Hiroaki Yamaguchi.
Estimation of blood sirolimus concentration based on tacrolimus concentration/dose normalized by body weight ratio in lung transplant patients.
Ther. Drug Monit., in press.

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