薬剤部の研究

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業績

 

2003年

Takashi Iida, Genta Kakiyama, Akari Shimada, Kumiko Mushiake, Nariyasu Mano, Junichi Goto and Toshio Nambara:
1H and 13C NMR signal assignments of carboxyl-linked glucosides of bile acids.
Magn. Reson. Chem., 41, 260-264 (2003).

Takashi Iida, Keisuke Shiraishi, Shoujiro Ogawa, Takaaki Goto, Nariyasu Mano, Junichi Goto and Toshio Nambara:
Functionalization of unactivated carbons in 3α,6- and 3α,24-dihydroxy-5β-cholane derivatives by dimethyldioxirane.
Lipids, 38, 281-287 (2003).

Nariyasu Mano, Takaaki Goto, Ayako Nikaido, Takashi Narui and Junichi Goto:
Inhibition of the rat hepatic microsomal flurbiprofen acyl glucuronidation by bile acids.
J. Pharm. Sci., 92, 2098-2108 (2003).
DOI: 10.1002/jps.10475

Nariyasu Mano, Akira Nishijima, Shuntaro Saito, Shigeo Ikegawa and Junichi Goto:
Synthesis and characterization of deoxycholyl 2-deoxyglucuronide: A water-soluble affinity labeling reagent.
Lipids, 38, 873-879 (2003).

Takashi Iida, Shoujiro Ogawa, Keisuke Shiraishi, Genta Kakiyama, Takaaki Goto, Nariyasu Mano and Junichi Goto:
A comparative study of remote oxy-functionalization of unactivated carbons in 5β-steroids by dimethyldioxirane and 2,6-dichloropyridine N-oxide/ruthenium-porphyrin/HBr.
Arkivoc, 2003(viii), 170-179 (2003).

Nariyasu Mano, Setsuko Iijima, Kie Kasuga and Junichi Goto:
Exopeptidase degradation for the analysis of phosphorylation site in a mono-phosphorylated peptide with matrix-assisted laser desorption/ionization mass spectrometry.
Anal. Sci., 19, 1469-1472 (2003).

Pi Sun, Norihiro Kobayashi and Junichi Goto:
Design and synthesis of 6α-corticosteroid haptens and their bovine serum albumin (BSA) conjugates.
Chinese Chem. Lett., 14, 259-??? (2003).

Norihiro Kobayashi, Kazuyuki Kubota, Hiroyuki Oiwa, Junichi Goto, Toshifumi Niwa and Koju Kobayashi:
Idiotype-anti-idiotype based noncompetitive enzyme-linked immunosorbent assay of ursodeoxycholic acid 7-N-acetylglucosaminides in human urine with subfemtomole range sensitivity.
J. Immunol. Methods, 272 (1,2), 1-10 (2003).

Naoto Suzuki, Takanori Hishinuma, Toshihide Saga, Jo Sato, Takayoshi Toyota, Junichi Goto and Michinao Mizugaki:
Determination of urinary 12(S)-hydroxyeicosatetraenoic acid by liquid chromatography/tandem mass spectrometry with column-switching technique: Sex difference in healthy volunteers and patients with diabetes mellitus.
J. Chromatogr. B, 783(2), 383-389 (2003).

Norihiro Kobayashi, Kazuki Shibusawa, Kazuyuki Kubota, Noriko Hasegawa, Pi Sun, Toshifumi Niwa and Junichi Goto:
Monoclonal anti-idiotype antibodies recognizing the variable region of a high affinity antibody against 11-deoxycortisol. Production, characterization and application to a sensitive non competitive immunoassay.
J. Immunol. Methods, 274, 63-75 (2003).

Lilian Rumi Tsuruta, Yoshihisa Tomioka, Takanori Hishinuma, Yoshinori Kato, Kunihiko Itoh, Toshio Suzuki, Hiroki Oguri, Masahiro Hirama, Junichi Goto and Michinao Mizugaki:
Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology.
Prostaglandins, Leukot. Essent. Fatty Acids, 68, 273-284 (2003).

Naoto Nakagawa, Takanori Hishinuma, Hitoshi Nakamura, Toru Yamazaki, Hiroki Tsukamoto, Masahiro Hiratsuka, Tatsuto Ido, Michinao Mizugaki, Tetsuya Terasaki and Junichi Goto:
Brain and heart specific alteration of methamphetamine (MAP) distribution in MAP-sensitized rat.
Biol. Pharm. Bull., 26, 506-509 (2003).

Takehiro Suzuki, Tohru Onogawa, Naoki Asano, Hiroya Mizutamari, Tsuyoshi Mikkaichi, Masayuki Tanemoto, Michiaki Abe, Fumitoshi Satoh, Michiaki Unno, Kazuo Nunoki, Masanori Suzuki, Takanori Hishinuma, Junichi Goto, Tooru Shimosegawa, Seiki Matsuno, Sadayoshi Ito, Takaaki Abe:
Identification and characterization of novel rat and human gonad-specific organic anion transporters.
Mol. Endocrinol. 17(7), 1203-1215 (2003).

Takashi Iida, Keisuke Shiraishi, Shoujiro Ogawa, Junichi Goto and Toshio Nambara:
An improved method for the capillary gas chromatographic derivatization of polyhydroxylated steroids having tert.-hydroxyl groups.
Anal. Sci., 19, 1317-1321 (2003).

Sookie La, Jiyung Kim, Jung-Han Kim, Junichi Goto and Kyoung-Rae Kim:
Simultaneous chiral discrimination of multiple profens by cyclodextrin-modified capillary electrophoresis in normal and reversed polarity modes.
Electrophoresis, 24, 2642-2649 (2003).

Mami Kida, Yutaka Mano, Yoshiyuki Ueno, Koju Kobayashi, Junichi Goto, Motoyasu Ishii and Tohr Shimosegawa:
Vectorial transport of bile acids in immortalized mouse bile duct cells.
Hepatology Res., 27, 151-157 (2003).

Hirotaka Kitada, Masaaki Miyata, Toshifumi Nakamura, Aki Tozawa, Wataru Honma, Miki Shimada, Kiyoshi Nagata, Christopher J. Sinal, Grace L. Guo, Frank J. Gonzalez and Yasushi Yamazoe:
Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
J. Biol. Chem., 278, 17838-17844 (2003).

Naoto Nakagawa, Takanori Hishinuma, Hitoshi Nakamura, Toru Yamazaki, Hiroki Tsukamoto, Masahiro Hiratsuka, Tatsuo Ido, Michinao Mizugaki, Tetsuya Terasaki and Junichi Goto:
Brain and heart specific alteration of methamphetamine (MAP) distribution in MAP-sensitized rat.
Biol Pharm Bull., 26, 506-509 (2003).

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