STUDY
業績

2025年

Mami Ishikuro, Taku Obara, Mayu Hasegawa, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Noriyuki Iwama, Masahiro Kikuya, Junichi Sugawara, Tatsuhiko Azegami, Takashin Nakayama, Asako Mito, Naoko Arata, Hirohito Metoki, Takeshi Kanda, Shinichi Kuriyama.
Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Hypertension Research, 48(1),68-76(2025).
DOI: 10.1038/s41440-024-01936-9

Ippei Takahashi, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Yoshikazu Nakayama, Atsushi Momose, Naho Tsuchiya, Satoshi Nagaie, Soichi Ogishima, Gen Tamiya, Nobuo Fuse, Atsushi Hozawa, Junichi Sugawara, Shigeo Kure, Shinichi Kuriyama.
Respiratory syncytial virus infection, non-respiratory syncytial virus respiratory infections, and later wheezing.
Pediatrics international, 67(1),e70050(2025).
DOI: 10.1111/ped.70050

Genki Shinoda, Fumiko Matsuzaki, Fumihiko Ueno, Mami Ishikuro, Keiko Murakami, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama.
Impact of Telework on Health and Lifestyle Changes During the COVID-19 Pandemic in Japan.
The Tohoku Journal of Experimental Medicine, in press (2025).
DOI: 10.1620/tjem.2025.J014

Keiko Murakami, Junko Ishihara, Ribeka Takachi, Shiori Sugawara, Misato Aizawa, Ippei Takahashi, Taku Obara, Mami Ishikuro, Aoi Noda, Mako Ogino, Yuchie Hoshina, Kumiko Kito, Misako Nakadate, Sachiko Maruya, Tomoka Matsuno, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Masayuki Yamamoto, Shinichi Kuriyama.
Validity and Reproducibility of Food Group Intakes in a Self-administered Food Frequency Questionnaire for Genomic and Omics Research: The Tohoku Medical Megabank Project.
Journal of Epidemiology, 35(3),109-117(2025).
DOI: 10.2188/jea.JE20240064

Chikana Kawaguchi, Maki Ozawa, Takanori Hidaka, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Masatsugu Orui, Taku Obara, Yumiko Ito, Takashi Kakinuma, Kazuhiro Kudoh, Hiroaki Ozawa, Satoshi Nakagawa, Masato Mizuashi, Ryoko Omori, Masatoshi Deguchi, Yumi Kanbayashi, Masayuki Asano, Toshiya Takahashi, Muneo Tanita, Masahiro
Hara, Kenshi Yamasaki, Takayoshi Tadaki, Hiromi Suzuki, Katsuko Kikuchi, Kenichiro Tsuchiyama, Takenobu Ohashi, Shu Sasai, Motoko Honda, Taku Fujimura, Sadanori Furudate, Yoshiko Kagimoto, Maki Kawamura, Nobuko Tabata, Rika Chikama, Hiromi Komatsu, Yota Sato, Kayo Tanita, Yutaka Kimura, Shino Yusa, Hitoshi Terui, Hisayuki Tono, Yusuke Muto, Shinichi Kuriyama, Masayuki Yamamoto, Setsuya Aiba.
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Allergology International, 74(2),246-253(2025).
DOI: 10.1016/j.alit.2024.09.008

Tomofumi Ishikawa, Takamasa Sakai, Aoi Noda, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara.
V Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study.
Journal of Affective Disorders, 374,640-645(2025).
DOI: 10.1016/j.jad.2025.01.044

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Akira Narita, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama.
Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study.
Scientific Reports, 15(1),13743(2025).
DOI: 10.1038/s41598-025-97291-x

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara.
Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
The Journal of Nutrition, 155(5),1498-1507(2025).
DOI: 10.1016/j.tjnut.2025.02.024

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara.
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women.
Journal of Human Genetics, 70 (5), 265-273 (2025).
DOI: 10.1038/s10038-025-01330-4

Fumihiko Ueno, Ippei Takahashi, Hisashi Ohseto, Tomomi Onuma, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumiko Matsuzaki, Hirohito Metoki, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama.
Deep-embedded clustering by relevant scales and genome-wide association study in autism.
PLoS One, 20 (5), e0322698 (2025).
DOI: 10.1371/journal.pone.0322698

Hisashi Ohseto, Mami Ishikuro, Geng Chen, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama.
Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes.
Scientific Reports, 15 (1), 18924 (2025).
DOI: 10.1038/s41598-025-03652-x

Masatsugu Orui, Mami Ishikuro, Taku Obara, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Tomoko Nishimura, Keiko Tanaka, Yoshihiro Miyake, Atsushi Hozawa, Kenji J Tsuchiya, Shinichi Kuriyama; Tohoku Medical Megabank Project Study Group.
Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large-scale community-based cohort study.
Psychiatry and Clinical Neurosciences Reports, 19 (2), e70095 (2025).
DOI: 10.1002/pcn5.70095

Mako Ogino, Ribeka Takachi, Junko Ishihara, Shiori Sugawara, Yuchie Hoshina, Kumiko Kito, Misako Nakadate, Sachiko Maruya, Aoi Suzuki, Tomoka Matsuno, Taku Obara, Mami Ishikuro, Fumihiko Ueno , Aoi Noda, Misato Aizawa, Ippei Takahashi, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Keiko Murakami, Shinichi Kuriyama.
Validity of single vs. multiple FFQs in ranking nutrient intake among Japanese adults: the Tohoku Medical Megabank Project.
Asia Pacific Journal of Clinical Nutrition, 34 (3), 451-468 (2025).
DOI: 10.6133/apjcn.202506_34(3).0019

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara.
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study.
Nutrition, 135, 112739 (2025).
DOI: 10.1016/j.nut.2025.112739

Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama.
Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Journal of Epidemiology, 35 (7), 305-312 (2025).
DOI: 10.2188/jea.JE20240293

Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Naoki Nakaya, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Makoto Sasaki, Atsushi Shimizu.
Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study.
American Journal of Human Genetics, 112 (8), 1852-1863 (2025).
DOI: 10.1016/j.ajhg.2025.06.015

Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, Junichi Sugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, Mika Sakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, Satoshi Nagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara, Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N Kodama, Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, Fumiki Katsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura, Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, Kengo Kinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama; Tohoku Medical Megabank Project Study Group.
Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update.
Int J Epidemiol, 54 (5), dyaf148 (2025).
DOI: 10.1093/ije/dyaf148

Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii.
Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study.
Frontiers in pharmacology, 16, 1562724 (2025).
DOI: 10.3389/fphar.2025.1562724

Chikana Kawaguchi, Mami Ishikuro, Ryota Saito, Keiko Murakami, Aoi Noda, Genki Shinoda, Misato Aizawa, Hisashi Ohseto, Noriyuki Iwama, Masatsugu Orui, Taku Obara, Shinichi Kuriyama.
Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children.
The Journal of Clinical Endocrinology and Metabolism, 110 (10), e3425-e3432 (2025).
DOI: 10.1210/clinem/dgae825

Shingo Nakashima, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Taku Obara, Shinichi Kuriyama.
Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
BioMed Central Pediatrics, 25 (1), 697 (2025).
DOI: 10.1186/s12887-025-06025-5

Koichi Sakakibara, Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Shinichi Kuriyama, Takeo Fujiwara, Pamela J Surkan.
Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study.
Journal of Diabetes Investigation, 16 (10), 1900-1909 (2025).
DOI: 10.1111/jdi.70101

Genki Shinoda, Taku Obara, Ippei Takahashi, Hisashi Ohseto, Chikana Kawaguchi, Akira Narita, Aoi Noda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Makiko Taira, Hiroshi Sakamoto, Naoki Nakaya, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Shunji Mugikura, Kyoko Suzuki, Shinichi Kuriyama.
Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.
Genes, Bbrain, and Behavior, 24 (5), e70038 (2025).
DOI: 10.1111/gbb.70038

Aoi Noda, Ryutaro Arita, Taku Obara, Minoru Ohsawa, Satoko Suzuki, Ken Haneda, Ryo Obara, Kei Morishita, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Shinichi Kuriyama.
Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy.
Pharmacoepidemiology and Ddrug Safety, 34 (11), e70251 (2025).
DOI: 10.1002/pds.70251

Geng Chen, Mami Ishikuro, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama.
Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy.
JAMA Network Open, 8 (11), e2545719 (2025).
DOI: 10.1001/jamanetworkopen.2025.45719

Hisashi Ohseto, Mami Ishikuro, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama.
The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women.
Placenta, 172, 100-103 (2025).
DOI: 10.1016/j.placenta.2025.10.017

Tadaharu Kunitoki, Takamasa Sakai, Tomofumi Ishikawa, Ryo Obara, Kei Morishita, Azusa Hara, Motohiko Adomi, Haruto Watanabe, Kaya Hayasaka, Yuna Yoshida, Aki Shimizu, Genki Shinoda, Aoi Noda, Mami Ishikuro, Masatsugu Orui, Noriyuki Iwama, Seiko Yamakoshi, Emiko Sato, Nariyasu Mano, Shinichi Kuriyama, Nobuyuki Takahashi, Taku Obara.
Risk of Major Congenital Malformations Associated With First-Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study.
Pharmacoepidemiology and Ddrug Safety, 34 (12), e70274 (2025).
DOI: 10.1002/pds.70274

Mustakim, Mami Ishikuro, Chikana Kawaguchi, Genki Shinoda, Aoi Noda, Masatsugu Orui, Keiko Murakami, Hirohito Metoki, Taku Obara, Shinichi Kuriyama.
Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Journal of Developmental Origins of Health and Disease, 16 , e46 (2025).
DOI: 10.1017/S2040174425100305

Masaki Kumondai, Ayaka Yagi, Masahiro Watanabe, Yanlin Lyu, Ryosuke Segawa, Mayumi Sato, Ryo Tadakuma, Kenji Inoue, Hideki Watanabe, Masahiro Takeda, Yoshiteru Ohshima, Masamitsu Maekawa, Nariyasu Mano.
Investigation of biomarkers for azole antifungal-induced liver injury using primary human hepatocyte spheroids.
Drug Metabolism and Disposition, 54(7), 100343 (2026).
DOI: 10.1016/j.dmd.2026.100343

Mao Maekawa, Masamitsu Maekawa, Yu Sato, Shimpei Watanabe, Masatoshi Saito, Nariyasu Mano.
Compatibility investigation of a steroid and two antibiotics with heparin for the prevention of catheter occlusion in neonatal intensive care units.
Methods and Protocols, 8 (6), 136 (2025).
DOI: 10.3390/mps8060136

Kei Morishita, Taku Obara, Tomofumi Ishikawa, Ryo Obara, Takamasa Sakai, Noriyuki Iwama,
Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroshi Kawame, Nariyasu Mano,
Shinichi Kuriyama.
Association of Quinolone Exposure in the First-Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan.
Pharmacoepidemiology and Drug Safety, 34 (9), e70190 (2025).
DOI: 10.1002/pds.70190

Toshihiro Sato, Takeshi Kawabata, Masaki Kumondai, Nagomi Hayashi, Hiroshi Komatsu, Yuki Kikuchi, Go Onoguchi, Yu Sato, Kei Nanatani, Masamitsu Maekawa, Masahiro Hiratsuka, Hiroaki Yamaguchi, Takaaki Abe, Hiroaki Tomita, Nariyasu Mano.
Effect of organic anion transporting polypeptide 1B1 on plasma concentration dynamics of clozapine in patients with treatment-resistant schizophrenia.
International Journal of Molecular Sciences, 25 (23), 13228 (2024).
DOI: https://doi.org/10.3390/ijms252313228